Comparison of the alpha-adrenergic agonists, phenylephrine and methoxamine in rabbit papillary muscles.
Abstract
The positive inotropic effects of the alpha-adrenergic agonists, phenylephrine and methoxamine were compared in isolated rabbit papillary muscles. Phenylephrine in the presence of 10(-7)M propranolol produced a greater response than methoxamine. Antagonism by phentolamine was competitive for phenylephrine and apparently, noncompetitive for methoxamine. Based upon observed maximum following frequencies, 10(-4)M methoxamine had a greater cardiac depressant effect than 10(-4) phenylephrine. It was suggested that phenylephrine with a beta-adrenergic antagonist possessed advantages over methoxamine as an agonist for studying cardiac alpha-adrenergic receptors in rabbit papillary muscles.
Topics
Field: Agricultural and Biological Sciences · Subfield: Animal Science and Zoology
Keywords
Methoxamine,Phenylephrine,Phentolamine,Propranolol,Agonist,Internal medicine,Endocrinology,Antagonist,Medicine,Chemistry
MeSH Terms
UN Sustainable Development Goals
- Good health and well-being (0.53)
All Available Versions
- Landing page — PubMed publishedVersion
- Landing page — PubMed
Citations by Year
| 2020 |
|---|
| 1 |
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