book-chapter Closed Access EN 2008-01-01

A Historical Perspective of Template-Based Protein Structure Prediction

Humana Press eBooks, Vol. 413, pp. 3–42 (2008)

University of Georgia

DOI: 10.1007/978-1-59745-574-9_1 PMID: 18075160

Abstract

This chapter presents a broad and a historical overview of the problem of protein structure prediction. Different structure prediction methods, including homology modeling, fold recognition (FR)/protein threading, ab initio/de novo approaches, and hybrid techniques involving multiple types of approaches, are introduced in a historical context. The progress of the field as a whole, especially in the threading/FR area, as reflected by the CASP/CAFASP contests, is reviewed. At the end of the chapter, we discuss the challenging issues ahead in the field of protein structure prediction.

Topics

Protein Structure and Dynamics 1.00 Enzyme Structure and Function 1.00 Microbial Metabolic Engineering and Bioproduction 1.00

Field: Biochemistry, Genetics and Molecular Biology · Subfield: Molecular Biology

Keywords

CASP,Threading (protein sequence),Protein structure prediction,Computer science,Homology modeling,Context (archaeology),Field (mathematics),Protein structure,Perspective (graphical),Computational biology