article Open Access (hybrid) EN 2010-12-11

Improved predictions by Pcons.net using multiple templates

Per Larsson, Marcin J. Skwark, Björn Wallner, Arne Elofsson

Bioinformatics, Vol. 27, Issue 3, pp. 426–427 (2010)

Stockholm University, Science for Life Laboratory, Swedish e-Science Research Centre

DOI: 10.1093/bioinformatics/btq664 PMID: 21149277

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Abstract

UNLABELLED: Multiple templates can often be used to build more accurate homology models than models built from a single template. Here we introduce PconsM, an automated protocol that uses multiple templates to build protein models. PconsM has been among the top-performing methods in the recent CASP experiments and consistently perform better than the single template models used in Pcons.net. In particular for the easier targets with many alternative templates with a high degree of sequence identity, quality is readily improved with a few percentages over the highest ranked model built on a single template. PconsM is available as an additional pipeline within the Pcons.net protein structure prediction server. AVAILABILITY AND IMPLEMENTATION: PconsM is freely available from http://pcons.net/.

Topics

Protein Structure and Dynamics 0.41 Bioinformatics and Genomic Networks 0.28 Machine Learning in Bioinformatics 0.07

Field: Biochemistry, Genetics and Molecular Biology · Subfield: Molecular Biology

Keywords

Template,CASP,Computer science,Pipeline (software),Protein structure prediction,Net (polyhedron),Data mining,Programming language,Protein structure,Biology

MeSH Terms

Models, MolecularModels, MolecularModels, MolecularModels, MolecularProteinsProteinsProteinsProteins

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