article Closed Access EN 2010-10-01

Evaluation of Antineoplastic Drug Exposure of Health Care Workers at Three University-Based US Cancer Centers

Thomas H. Connor, D. Gayle DeBord, Jack R. Pretty, M. Sieber Oliver, Tracy Roth, Peter S. J. Lees, Edward F. Krieg, Bonnie Rogers, Carmen P. Escalante, Christine Toennis, John C. Clark, Belinda C. Johnson, Melissa A. McDiarmid

Journal of Occupational and Environmental Medicine, Vol. 52, Issue 10, pp. 1019–1027 (2010)

University of Maryland, Baltimore, Centers for Disease Control and Prevention, The University of Texas MD Anderson Cancer Center, Johns Hopkins University, National Institute for Occupational Safety and Health, North Carolina Division of Public Health, Rogers (United States)

DOI: 10.1097/jom.0b013e3181f72b63 PMID: 20881620

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Abstract

OBJECTIVE: This study evaluated health care worker exposure to antineoplastic drugs. METHODS: A cross-sectional study examined environmental samples from pharmacy and nursing areas. A 6-week diary documented tasks involving those drugs. Urine was analyzed for two specific drugs, and blood samples were analyzed by the comet assay. RESULTS: Sixty-eight exposed and 53 nonexposed workers were studied. Exposed workers recorded 10,000 drug-handling events during the 6-week period. Sixty percent of wipe samples were positive for at least one of the five drugs measured. Cyclophosphamide was most commonly detected, followed by 5-fluorouracil. Three of the 68 urine samples were positive for one drug. No genetic damage was detected in exposed workers using the comet assay. CONCLUSIONS: Despite following recommended safe-handling practices, workplace contamination with antineoplastic drugs in pharmacy and nursing areas continues at these locations.

Topics

Safe Handling of Antineoplastic Drugs 1.00 Occupational and environmental lung diseases 0.00 Chemical Safety and Risk Management 0.00

Field: Health Professions · Subfield: Occupational Therapy

Keywords

Antineoplastic Drugs,Medicine,Occupational exposure,Drug,Cancer,Environmental health,Pharmacology,Internal medicine

MeSH Terms

Academic Medical CentersAcademic Medical CentersAcademic Medical CentersWorkforceWorkforceWorkforceAdultAdult

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Landing page — Journal of Occupational and Environmental Medicine publishedVersion
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APA

Thomas H. Connor, D. Gayle DeBord, Jack R. Pretty, M. Sieber Oliver, Tracy Roth, Peter S. J. Lees, Edward F. Krieg, Bonnie Rogers, Carmen P. Escalante, Christine Toennis, John C. Clark, Belinda C. Johnson, Melissa A. McDiarmid (2010). Evaluation of Antineoplastic Drug Exposure of Health Care Workers at Three University-Based US Cancer Centers. Journal of Occupational and Environmental Medicine, 52(10), 1019–1027. https://doi.org/10.1097/jom.0b013e3181f72b63

MLA

Thomas H. Connor, et al. "Evaluation of Antineoplastic Drug Exposure of Health Care Workers at Three University-Based US Cancer Centers." Journal of Occupational and Environmental Medicine, vol. 52, no. 10, 2010, pp. 1019–1027. https://doi.org/10.1097/jom.0b013e3181f72b63

Chicago

Thomas H. Connor, D. Gayle DeBord, Jack R. Pretty, M. Sieber Oliver, Tracy Roth, Peter S. J. Lees, Edward F. Krieg, Bonnie Rogers, Carmen P. Escalante, Christine Toennis, John C. Clark, Belinda C. Johnson, Melissa A. McDiarmid. "Evaluation of Antineoplastic Drug Exposure of Health Care Workers at Three University-Based US Cancer Centers." Journal of Occupational and Environmental Medicine 52, no. 10 (2010): 1019–1027. https://doi.org/10.1097/jom.0b013e3181f72b63

BibTeX

@article{connor2010,
  title = { Evaluation of Antineoplastic Drug Exposure of Health Care Workers at Three University-Based US Cancer Centers },
  author = { Thomas H. Connor and D. Gayle DeBord and Jack R. Pretty and M. Sieber Oliver and Tracy Roth and Peter S. J. Lees and Edward F. Krieg and Bonnie Rogers and Carmen P. Escalante and Christine Toennis and John C. Clark and Belinda C. Johnson and Melissa A. McDiarmid },
  journal = { Journal of Occupational and Environmental Medicine },
  year = { 2010 },
  volume = { 52 },
  number = { 10 },
  pages = { 1019--1027 },
  doi = { 10.1097/jom.0b013e3181f72b63 }
}

RIS

TY  - JOUR
TI  - Evaluation of Antineoplastic Drug Exposure of Health Care Workers at Three University-Based US Cancer Centers
AU  - Thomas H. Connor
AU  - D. Gayle DeBord
AU  - Jack R. Pretty
AU  - M. Sieber Oliver
AU  - Tracy Roth
AU  - Peter S. J. Lees
AU  - Edward F. Krieg
AU  - Bonnie Rogers
AU  - Carmen P. Escalante
AU  - Christine Toennis
AU  - John C. Clark
AU  - Belinda C. Johnson
AU  - Melissa A. McDiarmid
JO  - Journal of Occupational and Environmental Medicine
PY  - 2010
VL  - 52
IS  - 10
SP  - 1019
EP  - 1027
DO  - 10.1097/jom.0b013e3181f72b63
ER  -

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