article Closed Access EN 2011-03-14

Patterns of monoclonal immunoglobulins and serum free light chains are significantly different in black compared to white monoclonal gammopathy of undetermined significance (MGUS) patients

Brendan M. Weiss, Alex Minter, Jude Abadie, Robin Howard, Joao Ascencao, Geraldine P. Schechter, Michael Kuehl, Ola Landgren

American Journal of Hematology, Vol. 86, Issue 6, pp. 475–478 (2011)

Brooke Army Medical Center, United States Department of the Army, Wilford Hall Ambulatory Surgical Center, Walter Reed Army Institute of Research, George Washington University, Washington University Medical Center, National Institutes of Health

DOI: 10.1002/ajh.22025 PMID: 21544856

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Abstract

Monoclonal gammopathy of undetermined significance (MGUS), the precursor to multiple myeloma, is more common in blacks than whites. The serum free light chain (sFLC) assay is an important prognostic test in MGUS, but no study has evaluated sFLC levels and ratios in black MGUS patients. One-hundred and twenty-five black MGUS patients at two urban centers were compared to the white population of the Mayo Clinic. The median age for blacks was 73 years [41-94] and 75% were male. The M-protein isotype in blacks was 81% IgG, 13% IgA, 2% IgM, and 4% biclonal compared to 70%, 12%, 16%, and 2%, respectively, in whites, (P < 0.0005). The median M-protein concentration for blacks was 0.44 gm/dL (trace-2.33) compared to 1.2 gm/dl in whites. An abnormal sFLC ratio was present in 45% of black compared to 33% of white (P = 0.01) patients. Using the Mayo Clinic risk model, black patients had a significantly lower proportion of higher risk MGUS compared to whites: low 43%, low-intermediate 45%, high-intermediate 10%, and high 2% (P = 0.014). Black patients with MGUS have significantly different laboratory findings compared to whites. The biologic basis for these disparities and their effect on prognostic assessment is unknown. Prognostic models based on these biomarkers should be used cautiously in nonwhite populations.

Topics

Multiple Myeloma Research and Treatments 1.00 Glycosylation and Glycoproteins Research 1.00 Chronic Lymphocytic Leukemia Research 1.00

Field: Medicine · Subfield: Hematology

Keywords

Monoclonal gammopathy of undetermined significance,Medicine,Multiple myeloma,Isotype,Internal medicine,Gastroenterology,Population,Immunoglobulin light chain,Antibody,Monoclonal

MeSH Terms

AdultAdultAdultAgedAgedAgedAged, 80 and overAged, 80 and over

UN Sustainable Development Goals

Sustainable cities and communities (0.73)

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APA

Brendan M. Weiss, Alex Minter, Jude Abadie, Robin Howard, Joao Ascencao, Geraldine P. Schechter, Michael Kuehl, Ola Landgren (2011). Patterns of monoclonal immunoglobulins and serum free light chains are significantly different in black compared to white monoclonal gammopathy of undetermined significance (MGUS) patients. American Journal of Hematology, 86(6), 475–478. https://doi.org/10.1002/ajh.22025

MLA

Brendan M. Weiss, et al. "Patterns of monoclonal immunoglobulins and serum free light chains are significantly different in black compared to white monoclonal gammopathy of undetermined significance (MGUS) patients." American Journal of Hematology, vol. 86, no. 6, 2011, pp. 475–478. https://doi.org/10.1002/ajh.22025

Chicago

Brendan M. Weiss, Alex Minter, Jude Abadie, Robin Howard, Joao Ascencao, Geraldine P. Schechter, Michael Kuehl, Ola Landgren. "Patterns of monoclonal immunoglobulins and serum free light chains are significantly different in black compared to white monoclonal gammopathy of undetermined significance (MGUS) patients." American Journal of Hematology 86, no. 6 (2011): 475–478. https://doi.org/10.1002/ajh.22025

BibTeX

@article{weiss2011,
  title = { Patterns of monoclonal immunoglobulins and serum free light chains are significantly different in black compared to white monoclonal gammopathy of undetermined significance (MGUS) patients },
  author = { Brendan M. Weiss and Alex Minter and Jude Abadie and Robin Howard and Joao Ascencao and Geraldine P. Schechter and Michael Kuehl and Ola Landgren },
  journal = { American Journal of Hematology },
  year = { 2011 },
  volume = { 86 },
  number = { 6 },
  pages = { 475--478 },
  doi = { 10.1002/ajh.22025 }
}

RIS

TY  - JOUR
TI  - Patterns of monoclonal immunoglobulins and serum free light chains are significantly different in black compared to white monoclonal gammopathy of undetermined significance (MGUS) patients
AU  - Brendan M. Weiss
AU  - Alex Minter
AU  - Jude Abadie
AU  - Robin Howard
AU  - Joao Ascencao
AU  - Geraldine P. Schechter
AU  - Michael Kuehl
AU  - Ola Landgren
JO  - American Journal of Hematology
PY  - 2011
VL  - 86
IS  - 6
SP  - 475
EP  - 478
DO  - 10.1002/ajh.22025
ER  -

Citations

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3.56

FWCI

93%

Normalized Pctile

References

Authors