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VM

Vamsi K. Mootha

Broad Institute US

ORCID 0000-0001-9924-642X
367
Publications
125,851
Citations
109
H-Index
195
i10-Index
9.69
2yr Mean Cite
-
Cite/Paper
Data combined from OpenAlex + Semantic Scholar. OA = OpenAlex S2 = Semantic Scholar
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Publication & Citation Trends

Most Cited Works

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles OA
Aravind Subramanian, Pablo Tamayo, Vamsi K. Mootha, Sayan Mukherjee, Benjamin L. Ebert +6 more
Proceedings of the National Academy of Sciences 2005
55,693
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Vamsi K. Mootha, Cecilia M. Lindgren, Karl‐Fredrik Eriksson, Aravind Subramanian, Smita Sihag +16 more
Nature Genetics 2003
10,506
Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 OA
Zhidan Wu, Pere Puigserver, Jan Andersson, Chen‐Yu Zhang, Guillaume Adelmant +6 more
Cell 1999
4,081
Metabolite profiles and the risk of developing diabetes OA
Thomas J. Wang, Martin G. Larson, Ramachandran S. Vasan, Susan Cheng, Eugene P. Rhee +13 more
Nature Medicine 2011
3,113
A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology OA
David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai +11 more
Cell 2008
1,992

Publications

363 total

Dynamic optical coherence tomography links mitochondrial ATP activity to subcellular motion in ex-vivo tissue

Milana Kendrisic, Hinnerk Schulz-Hildebrandt, Michelle Yue, J. Gardecki, R. Hanke - Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXX, 2026
Cited by 0 Semantic Scholar

Hypoxia as a medicine

Robert S Rogers, V. Mootha - Science Translational Medicine, 2025
Cited by 16 Semantic Scholar

Mechanism of age-related accumulation of mitochondrial DNA mutations in human blood

Rahul Gupta, Timothy J. Durham, G. Chau, M. Uddin, Wenhan Lu - bioRxiv, 2025
Cited by 3 Semantic Scholar

Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency

Joshua D. Meisel, Pallavi R. Joshi, Amy N Spelbring, Hong Wang, Sandra M Wellner - Nature, 2025
Cited by 2 Semantic Scholar

Multiomic analysis reveals a key BCAT1 role in mTOR activation by B cell receptor and TLR9

Rui Guo, Yizhe Sun, Matthew Lim, Hardik Shah, Joao A. Paulo - Journal of Clinical Investigation, 2025
Cited by 1 Semantic Scholar

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease

Eizo Marutani, Maria Miranda, Timothy J. Durham, Sharon H. Kim, Dreson L Russell - Nature Neuroscience, 2025
Cited by 8 Semantic Scholar

The proton motive force maintains mtDNA euploidy by balancing mtDNA replication with cell proliferation

S. Rath, V. Mootha - bioRxiv, 2025
Cited by 0 Semantic Scholar

Multi-omic Analysis of Human B-cell Activation Reveals a Key Lysosomal BCAT1 Role in mTOR Hyperactivation by B-cell receptor and TLR9 OA

Benjamin E. Gewurz, Rui Guo, Matthew Lim, Hardik Shah, João A. Paulo - Research Square, 2024
Cited by 1 Semantic Scholar

Differential utilization of vitamin B12-dependent and independent pathways for propionate metabolism across human cells OA

H. Gouda, Yuanyuan Ji, S. Rath, David Watkins, David Rosenblatt - Journal of Biological Chemistry, 2024
Cited by 6 Semantic Scholar

Mechanism of Action and Translational Potential of (S)-Meclizine in Preemptive Prophylaxis Against Stroke

Jeong Hyun Lee, Vishal M. Gohil, P. Heidari, Jessica L. Seidel, M. Zulkifli - Stroke, 2024
Cited by 2 Semantic Scholar

Research Topics

Mitochondrial Function and Pathology (210) Metabolism and Genetic Disorders (86) RNA modifications and cancer (60) ATP Synthase and ATPases Research (59) Adipose Tissue and Metabolism (42)

Frequent Co-Authors

TO
Todd R. Golub
3 joint publications
ER
Eric S. Lander
3 joint publications
PE
Pere Puigserver
3 joint publications
BR
Bruce M. Spiegelman
3 joint publications
SA
Sarah E. Calvo
3 joint publications
AR
Aravind Subramanian
2 joint publications

Affiliations

Broad Institute
US 2025 - 2004
Boston University
US 2013 - 2013
Tufts University
US 2018 - 2018
Brigham and Women's Hospital
US 2004 - 2000
Leeds General Infirmary
GB 2016 - 2016

External Profiles

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