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Grace Ka Yan Chan

Toxicologie, Pharmacologie et Signalisation Cellulaire FR

7
Publications
311
Citations
6
H-Index
6
i10-Index
0
2yr Mean Cite
-
Cite/Paper
Data combined from OpenAlex + Semantic Scholar. OA = OpenAlex S2 = Semantic Scholar
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Publication & Citation Trends

Most Cited Works

A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays OA
Grace Ka Yan Chan, Tracy Kleinheinz, David Peterson, John G. Moffat
PLoS ONE 2013
164
Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) OA
Bryan Chan, Eileen M. Seward, Michael Lainchbury, Thomas F. Brewer, Le An +22 more
ACS Medicinal Chemistry Letters 2021
42
Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma OA
Xiaojing Wang, Wesley Blackaby, Vivienne Allen, Grace Ka Yan Chan, Jae H. Chang +29 more
Journal of Medicinal Chemistry 2019
36
Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors OA
Huiyong Hu, Xiaojing Wang, Grace Ka Yan Chan, Jae H. Chang, Steven Do +11 more
Bioorganic & Medicinal Chemistry Letters 2015
27
Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors OA
Dennis X. Hu, Snahel Patel, Huifen Chen, Shu‐Mei Wang, Steven T. Staben +19 more
Journal of Medicinal Chemistry 2021
22

Publications

7 total

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1) PDF

Bryan Chan, Eileen M. Seward, Michael Lainchbury, Thomas F. Brewer, Le An et al. - ACS Medicinal Chemistry Letters, 2021
Cited by 42 OpenAlex

Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors PDF

Dennis X. Hu, Snahel Patel, Huifen Chen, Shu‐Mei Wang, Steven T. Staben et al. - Journal of Medicinal Chemistry, 2021
Cited by 22 OpenAlex

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma PDF

Xiaojing Wang, Wesley Blackaby, Vivienne Allen, Grace Ka Yan Chan, Jae H. Chang et al. - Journal of Medicinal Chemistry, 2019
Cited by 36 OpenAlex

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability.

Xiaojing Wang, A. Kolesnikov, Suzanne Tay, G. Chan, Q. Chao - Journal of Medicinal Chemistry, 2017
Cited by 24 Semantic Scholar

Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors PDF

Huiyong Hu, Xiaojing Wang, Grace Ka Yan Chan, Jae H. Chang, Steven Do et al. - Bioorganic & Medicinal Chemistry Letters, 2015
Cited by 27 OpenAlex

Unlocking the Potential of High-Throughput Drug Combination Assays Using Acoustic Dispensing PDF

Grace Ka Yan Chan, Stacy Wilson, Stephen D. Schmidt, John G. Moffat - SLAS TECHNOLOGY, 2015
Cited by 20 OpenAlex

Comparison of ATP and MTS assays with direct cell counting for multiple cell lines. PDF

Grace Ka Yan Chan, Tracy Kleinheinz, David M. Peterson, John G. Moffat - Figshare, 2015
Cited by 0 OpenAlex

Abstract B22: Potential combinatorial strategies to overcome drug resistance in BRAF-mutant melanoma

Nicholas A Dompe, Eva Lin, Jing Peng, G. Chan, Janet Y. Tien - Unknown Venue, 2015
Cited by 0 Semantic Scholar

Abstract 740: Phenotypic profiling and selectivity optimization of ERK inhibitors using a high-throughput imaged-based cell cycle assay

G. Chan, Tracy Kleinheinz, Matthew Martinson, Hok-Sum Cheung, John G. Moffat - Unknown Venue, 2014
Cited by 0 Semantic Scholar

A Simple High-Content Cell Cycle Assay Reveals Frequent Discrepancies between Cell Number and ATP and MTS Proliferation Assays PDF

Grace Ka Yan Chan, Tracy Kleinheinz, David Peterson, John G. Moffat - PLoS ONE, 2013
Cited by 164 OpenAlex

Research Topics

Cell Image Analysis Techniques (3) Melanoma and MAPK Pathways (2) Phytochemical compounds biological activities (2) Cancer Mechanisms and Therapy (2) Computational Drug Discovery Methods (1)

Frequent Co-Authors

JO
John G. Moffat
7 joint publications
TR
Tracy Kleinheinz
2 joint publications
JA
Jason Drummond
2 joint publications
JO
Jodie Pang
2 joint publications
LA
Laurent Salphati
2 joint publications
CH
Christopher J. Sneeringer
2 joint publications

Affiliations

Biochemical Society
GB 2013 - 2013
Toxicologie, Pharmacologie et Signalisation Cellulaire
FR 2021 - 2021

External Profiles

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