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NK

Nicholas Keen

Independent Researcher

ORCID 0000-0003-0741-3716
150
Publications
10,477
Citations
34
H-Index
41
i10-Index
0.8
2yr Mean Cite
-
Cite/Paper
Data combined from OpenAlex . OA = OpenAlex S2 = Semantic Scholar
Verify on Google Scholar

Publication & Citation Trends

Most Cited Works

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response
Hui Gao, Joshua M. Korn, Stéphane Ferretti, John E. Monahan, Youzhen Wang +59 more
Nature Medicine 2015
1,424
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores OA
Claire Ditchfield, Victoria Johnson, Anthony Tighe, Rebecca Ellston, Carolyn Haworth +4 more
The Journal of Cell Biology 2003
1,187
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan, Peter Fekkes, Jorge García‐Fortanet +48 more
Nature 2016
912
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening OA
E. Robert McDonald, Antoine de Weck, Michael R. Schlabach, Éric Billy, Konstantinos J. Mavrakis +95 more
Cell 2017
693
Aurora-kinase inhibitors as anticancer agents
Nicholas Keen, Stephen S. Taylor
Nature reviews. Cancer 2004
679

Publications

150 total

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening PDF

E. Robert McDonald, Antoine de Weck, Michael R. Schlabach, Éric Billy, Konstantinos J. Mavrakis et al. - Cell, 2017
Cited by 693 OpenAlex

The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1

Andrew A. Wylie, Joseph Schoepfer, Wolfgang Jahnke, Sandra W. Cowan‐Jacob, Alice Loo et al. - Nature, 2017
Cited by 584 OpenAlex

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan, Peter Fekkes, Jorge García‐Fortanet et al. - Nature, 2016
Cited by 912 OpenAlex

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis, E. Robert McDonald, Michael R. Schlabach, Éric Billy, Gregory R. Hoffman et al. - Science, 2016
Cited by 556 OpenAlex

CRISPR Screens Provide a Comprehensive Assessment of Cancer Vulnerabilities but Generate False-Positive Hits for Highly Amplified Genomic Regions

Diana M. Muñoz, Pamela J. Cassiani, Li Li, Éric Billy, Joshua M. Korn et al. - Cancer Discovery, 2016
Cited by 396 OpenAlex

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

Hui Gao, Joshua M. Korn, Stéphane Ferretti, John E. Monahan, Youzhen Wang et al. - Nature Medicine, 2015
Cited by 1,424 OpenAlex

Studying clonal dynamics in response to cancer therapy using high-complexity barcoding

Hyo-Eun Carrie Bhang, David A. Ruddy, Viveksagar Krishnamurthy Radhakrishna, Justina X. Caushi, Rui Zhao et al. - Nature Medicine, 2015
Cited by 524 OpenAlex

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers PDF

Gregory R. Hoffman, Rami Rahal, Frank P. Buxton, Kay X. Xiang, Gregory McAllister et al. - Proceedings of the National Academy of Sciences, 2014
Cited by 410 OpenAlex

Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia PDF

Jacob D. Jaffe, Yan Wang, Ho Man Chan, Jinghui Zhang, Robert Huether et al. - Nature Genetics, 2013
Cited by 283 OpenAlex

Structural Basis of Substrate Methylation and Inhibition of SMYD2 PDF

Andrew D. Ferguson, Nicholas Larsen, Tina Howard, Hannah Pollard, Isabelle Green et al. - Structure, 2011
Cited by 194 OpenAlex

Research Topics

Monoclonal and Polyclonal Antibodies Research (26) Immunotherapy and Immune Responses (21) CRISPR and Genetic Engineering (18) Cancer Mechanisms and Therapy (18) Microtubule and mitosis dynamics (17)

Frequent Co-Authors

WI
William R. Sellers
8 joint publications
FR
Frank Stegmeier
6 joint publications
E.
E. Robert McDonald
5 joint publications
DA
David A. Ruddy
5 joint publications
K.
K. Venkatesan
5 joint publications
FR
Francesco Hofmann
5 joint publications

Affiliations

AstraZeneca (United Kingdom)
GB 2009 - 2003
Novartis (Switzerland)
CH 2017 - 2014
Foundation for Biomedical Research
US 2015 - 2014
University of Leeds
GB 1998 - 1998
Boston Biomedical Research Institute
US 2019 - 2019

External Profiles

OpenAlex Profile Search Semantic Scholar ORCID Profile Google Scholar

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