Irina Chuckowree

UCB Pharma (United Kingdom) GB

Publications

2,180

Citations

H-Index

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Data combined from OpenAlex + Semantic Scholar. OA = OpenAlex S2 = Semantic Scholar

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Publication & Citation Trends

Most Cited Works

The Identification of 2-(1<i>H</i>-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-<i>d</i>]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer OA

Adrian Folkes, Khatereh Ahmadi, W. Alderton, Sonia Alix, Stewart Baker +29 more

Journal of Medicinal Chemistry 2008

741

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941 OA

Florence I. Raynaud, Suzanne A. Eccles, Sonal Patel, Sonia Alix, Gary Box +19 more

Molecular Cancer Therapeutics 2009

271

Small molecule induced reactivation of mutant p53 in cancer cells OA

Xiangrui Liu, Rainer Wilcken, Andreas C. Joerger, Irina Chuckowree, Jahangir Amin +2 more

Nucleic Acids Research 2013

230

Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer OA

Daniel P. Sutherlin, Linda Bao, Megan Berry, Georgette M. Castanedo, Irina Chuckowree +26 more

Journal of Medicinal Chemistry 2011

215

Novel Angular Benzophenazines: Dual Topoisomerase I and Topoisomerase II Inhibitors as Potential Anticancer Agents

Nigel Vicker, Luke Burgess, Irina Chuckowree, Rory Dodd, Adrian Folkes +13 more

Journal of Medicinal Chemistry 2002

133

Publications

49 total

Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion PDF

G. Stuart Cockerill, Richard Angell, Alexandre F. Bedernjak, Irina Chuckowree, Ian S. Fraser et al. - Journal of Medicinal Chemistry, 2021

Cited by 68 OpenAlex

Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors PDF

Oraphan Phuangsawai, Paul Beswick, Siriluk Ratanabunyong, Lueacha Tabtimmai, Praphasri Suphakun et al. - European Journal of Medicinal Chemistry, 2016

Cited by 28 OpenAlex

Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells OA

M. Bagley, Mohammed A. Baashen, Irina S. Chuckowree, J. Dwyer, D. Kipling - Pharmaceuticals, 2015

Cited by 8 Semantic Scholar

Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells OA

A. Longo, Mariangela Librizzi, Irina S. Chuckowree, C. Baltus, J. Spencer - Molecules, 2015

Cited by 8 Semantic Scholar

Synthesis of hybrid anticancer agents based on kinase and histone deacetylase inhibitors PDF

Hiren Patel, Irina Chuckowree, Peter Coxhead, Matthew Guille, Minghua Wang et al. - MedChemComm, 2014

Cited by 20 OpenAlex

Small molecule induced reactivation of mutant p53 in cancer cells PDF

Xiangrui Liu, Rainer Wilcken, Andreas C. Joerger, Irina Chuckowree, Jahangir Amin et al. - Nucleic Acids Research, 2013

Cited by 230 OpenAlex

Targeting Epidermal Growth Factor Receptor with Ferrocene-Based Kinase Inhibitors PDF

Jahangir Amin, Irina Chuckowree, Graham J. Tizzard, Simon J. Coles, Minghua Wang et al. - Organometallics, 2013

Cited by 24 OpenAlex

Synthesis of Oxindole-Based Bioorganometallic Kinase Inhibitors Incorporating One or More Ferrocene Groups PDF

Jahangir Amin, Irina Chuckowree, Minghua Wang, Graham J. Tizzard, Simon J. Coles et al. - Organometallics, 2013

Cited by 23 OpenAlex

Olefin cross-metathesis/Suzuki–Miyaura reactions on vinylphenylboronic acid pinacol esters

C. Baltus, Irina S. Chuckowree, N. Press, I. J. Day, S. Coles - Unknown Venue, 2013

Cited by 13 Semantic Scholar

Abstract 2472: Small-molecule-induced reactivation of mutant p53 in cancer cells.

Xiangrui Liu, R. Wilcken, A. Joerger, Irina S. Chuckowree, J. Spencer - Unknown Venue, 2013

Cited by 1 Semantic Scholar

Research Topics

PI3K/AKT/mTOR signaling in cancer (20) Protein Kinase Regulation and GTPase Signaling (15) Biochemical and Molecular Research (14) Crystallization and Solubility Studies (10) X-ray Diffraction in Crystallography (10)

Frequent Co-Authors

Adrian Folkes

8 joint publications

Nan Chi Wan

6 joint publications

Alan G. Olivero

5 joint publications

Jodie Pang

5 joint publications

Laurent Salphati

5 joint publications

Lori S. Friedman

4 joint publications

Affiliations

Institute of Cancer Research

GB 2009 - 2008

University of Auckland

NZ 2002 - 2002

University of Sussex

GB 2021 - 2013

MRC Laboratory of Molecular Biology

GB 2013 - 2013

Cancer Research UK

GB 2009 - 2008

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Irina Chuckowree

Publication & Citation Trends

Most Cited Works

Publications

Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells OA

Cytotoxicity of the Urokinase-Plasminogen Activator Inhibitor Carbamimidothioic Acid (4-Boronophenyl) Methyl Ester Hydrobromide (BC-11) on Triple-Negative MDA-MB231 Breast Cancer Cells OA

Research Topics

Frequent Co-Authors

Affiliations

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