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Benjamin J. Burke

Johns Hopkins University US

41
Publications
2,107
Citations
15
H-Index
17
i10-Index
4.0
2yr Mean Cite
-
Cite/Paper
Data combined from OpenAlex + Semantic Scholar. OA = OpenAlex S2 = Semantic Scholar
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Publication & Citation Trends

Most Cited Works

Discovery of (10 <i>R</i> )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- <i>2H</i> -8,4-(metheno)pyrazolo[4,3- <i>h</i> ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations OA
Ted W. Johnson, Paul Richardson, Simon Bailey, Alexei Brooun, Benjamin J. Burke +28 more
Journal of Medicinal Chemistry 2014
578
Resensitization to Crizotinib by the Lorlatinib<i>ALK</i>Resistance Mutation L1198F OA
Alice T. Shaw, Luc Friboulet, Ignaty Leshchiner, Justin F. Gainor, Simon Bergqvist +18 more
New England Journal of Medicine 2015
484
Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound <i>ALK</i> Mutations in ALK-Positive Lung Cancer OA
Satoshi Yoda, W. Marston Linehan, Michael S. Lawrence, Benjamin J. Burke, Luc Friboulet +20 more
Cancer Discovery 2018
304
Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. 4. Incorporation of P<sub>1</sub> Lactam Moieties as <scp>l</scp>-Glutamine Replacements OA
Peter S. Dragovich, Thomas J. Prins, Ru Zhou, Stephen E. Webber, Joseph Marakovits +15 more
Journal of Medicinal Chemistry 1999
189
Design of Potent and Selective Inhibitors to Overcome Clinical Anaplastic Lymphoma Kinase Mutations Resistant to Crizotinib OA
Qinhua Huang, Ted W. Johnson, Simon Bailey, Alexei Brooun, Kevin D. Bunker +36 more
Journal of Medicinal Chemistry 2014
118

Publications

41 total

Abstract LB028: Discovery and characterization of selective heterobifunctional degraders of EP300 in hematopoietic malignancies

Frederick A. Derheimer, Ninvita Givarkes, Natalie Miller, Rita Grantner, Casey Quinlan - Cancer Research, 2024
Cited by 1 Semantic Scholar

Development and Comprehensive Benchmark of a High-Quality AMBER-Consistent Small Molecule Force Field with Broad Chemical Space Coverage for Molecular Modeling and Free Energy Calculation

Xue Bai, Qingyi Yang, Qiaochu Zhang, Xiao Wan, Dong Fang et al. - Journal of Chemical Theory and Computation, 2023
Cited by 18 OpenAlex

1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long–sought-after mimetics for <i>ortho</i> / <i>meta</i> -substituted arenes PDF

Jin‐Xin Zhao, Yuxuan Chang, Chi He, Benjamin J. Burke, Michael R. Collins et al. - Proceedings of the National Academy of Sciences, 2021
Cited by 111 OpenAlex

Characterization of Specific <i>N</i> -α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library PDF

Pei‐Pei Kung, Patrick Bingham, Benjamin J. Burke, Qiuxia Chen, Xue‐Min Cheng et al. - ACS Medicinal Chemistry Letters, 2020
Cited by 35 OpenAlex

Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library. OA

P. Kung, P. Bingham, B. Burke, Qiuxia Chen, Xuemin Cheng - ACS Medicinal Chemistry Letters, 2020
Cited by 21 Semantic Scholar

Sequential ALK Inhibitors Can Select for Lorlatinib-Resistant Compound <i>ALK</i> Mutations in ALK-Positive Lung Cancer PDF

Satoshi Yoda, W. Marston Linehan, Michael S. Lawrence, Benjamin J. Burke, Luc Friboulet et al. - Cancer Discovery, 2018
Cited by 304 OpenAlex

Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F. OA

A. Shaw, L. Friboulet, I. Leshchiner, J. Gainor, S. Bergqvist - New England Journal of Medicine, 2016
Cited by 454 Semantic Scholar

Resensitization to Crizotinib by the Lorlatinib<i>ALK</i>Resistance Mutation L1198F PDF

Alice T. Shaw, Luc Friboulet, Ignaty Leshchiner, Justin F. Gainor, Simon Bergqvist et al. - New England Journal of Medicine, 2015
Cited by 484 OpenAlex

Effect of water solvation on the lipophilicity of isomeric pyrimidine-carboxamides.

M. A. Linton, B. Burke, T. Johnson, S. Ninkovic, K. Gajiwala - Bioorganic & Medicinal Chemistry, 2015
Cited by 5 Semantic Scholar

Discovery of (10 <i>R</i> )-7-Amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro- <i>2H</i> -8,4-(metheno)pyrazolo[4,3- <i>h</i> ][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile (PF-06463922), a Macrocyclic Inhibitor of Anaplastic Lymphoma Kinase (ALK) and c-ros Oncogene 1 (ROS1) with Preclinical Brain Exposure and Broad-Spectrum Potency against ALK-Resistant Mutations PDF

Ted W. Johnson, Paul Richardson, Simon Bailey, Alexei Brooun, Benjamin J. Burke et al. - Journal of Medicinal Chemistry, 2014
Cited by 578 OpenAlex

Research Topics

Lung Cancer Treatments and Mutations (13) Lung Cancer Research Studies (12) Cancer therapeutics and mechanisms (11) Protein Structure and Dynamics (5) Mass Spectrometry Techniques and Applications (5)

Frequent Co-Authors

SE
Sergei Timofeevski
5 joint publications
TE
Ted W. Johnson
4 joint publications
PA
Paul Richardson
4 joint publications
YA
Ya‐Li Deng
4 joint publications
SI
Simon Bailey
3 joint publications
AL
Alexei Brooun
3 joint publications

Affiliations

Johns Hopkins University
US 2024 - 2024
Pfizer (United States)
US 2024 - 2009
Johns Hopkins Medicine
US 2024 - 2024
Wright-Patterson Air Force Base
US 2019 - 2019
University of Illinois Chicago
US 1994 - 1990

External Profiles

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