Lenny Dang

Agios Pharmaceuticals (United States) US

0000-0002-2073-6109

134

Publications

15,176

Citations

H-Index

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2yr Mean Cite

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Data combined from OpenAlex + Semantic Scholar. OA = OpenAlex S2 = Semantic Scholar

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Publication & Citation Trends

Most Cited Works

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate OA

Lenny Dang, David W. White, Stefan Größ, Bryson D. Bennett, Mark Bittinger +15 more

Nature 2009

4,082

Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma OA

Christina M. Annunziata, R. Eric Davis, Yulia N. Demchenko, William Bellamy, Ana Gabrea +17 more

Cancer Cell 2007

945

NF-κB as a Therapeutic Target in Multiple Myeloma OA

Teru Hideshima, Dharminder Chauhan, Paul G. Richardson, Constantine S. Mitsiades, Nicholas Mitsiades +7 more

Journal of Biological Chemistry 2002

892

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis OA

Dimitrios Anastasiou, Yimin Yu, William J. Israelsen, Jian‐kang Jiang, Matthew B. Boxer +38 more

Nature Chemical Biology 2012

816

Targeted Inhibition of Mutant IDH2 in Leukemia Cells Induces Cellular Differentiation

Fang Wang, Jeremy Travins, Byron DeLaBarre, Virginie Penard‐Lacronique, Stefanie S. Schalm +26 more

Science 2013

792

Publications

134 total

The Pyruvate Kinase (PK) Activator AG-946 Improves PK Properties and Red Blood Cell (RBC) Characteristics upon Ex Vivo treatment of RBCs from Patients with Myelodysplastic Syndromes OA

Jonathan R. A. de Wilde, Titine J J Ruiter, B. V. van Oirschot, J. J. Jans, L. Dang - Blood, 2023

Cited by 1 Semantic Scholar

Mitapivat reprograms the RBC metabolome and improves anemia in a mouse model of hereditary spherocytosis OA

A. Matte, A. B. Wilson, Federica Gevi, E. Federti, A. Recchiuti - JCI Insight, 2023

Cited by 7 Semantic Scholar

Structure‐Based Design of AG‐946, a Pyruvate Kinase Activator

Tao Liu, Anil K. Padyana, Evan T. Judd, Lei-Yang Jin, Dalia Hammoudeh - ChemMedChem, 2023

Cited by 7 Semantic Scholar

P1485: PKM AND PKR EXPRESSION DURING HEMATOPOIESIS AND ERYTHROPOIESIS OA

Erin Tsai, Leonardo Rivadeneyra, S. Yilmaz, L. Dang, M. Wind-Rotolo - HemaSphere, 2023

Cited by 0 Semantic Scholar

P717: AG946, A PYRUVATE KINASE (PK) ACTIVATOR IMPROVES PK PROPERTIES AND RED BLOOD CELL (RBC) METABOLISM UPON EX VIVO TREATMENT OF RBCS FROM PATIENTS WITH MYELODYSPLASTIC SYNDROMES OA

Jonathan R. A. de Wilde, Titine J J Ruiter, B. V. van Oirschot, J. Jans, L. Dang - HemaSphere, 2023

Cited by 1 Semantic Scholar

Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in β-thalassemic mice OA

A. Matte, P. Kosinski, E. Federti, L. Dang, A. Recchiuti - Haematologica, 2023

Cited by 10 Semantic Scholar

AG-946, an Activator of Pyruvate Kinase, Improves Ineffective Erythropoiesis in the Bone Marrow of Mouse Models of Myelodysplastic Syndromes OA

Alexandra Bunda, Hui Gao, Cecelia Burgwardt, Christy Ingersoll, Rohitash Jamwal - Blood, 2023

Cited by 1 Semantic Scholar

AG-946 Normalizes Glycolysis and Improves Red Cell Indices in a Humanized Sickle Cell Mouse Model OA

R. Jamwal, Lily C. Wain, Christopher Copeland, P. Kosinski, M. Wind-Rotolo - Blood, 2022

Cited by 2 Semantic Scholar

A Phase 1 Dose Escalation Study of the Pyruvate Kinase Activator Mitapivat (AG-348) in Sickle Cell Disease. OA

J. Xu, Anna K. Conrey, I. Frey, Eveline Gwaabe, Laurel Menapace - Blood, 2022

Cited by 57 Semantic Scholar

Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model. OA

Z. Quezado, Sayuri Kamimura, Meghann L. Smith, Xunde Wang, M. R. Heaven - Blood Cells, Molecules & Diseases, 2022

Cited by 28 Semantic Scholar

Research Topics

Cancer, Hypoxia, and Metabolism (30) Erythrocyte Function and Pathophysiology (26) Acute Myeloid Leukemia Research (24) Hemoglobinopathies and Related Disorders (18) Biochemical and Molecular Research (17)

Frequent Co-Authors

Shengfang Jin

7 joint publications

Katharine Yen

7 joint publications

Shinsan M. Su

7 joint publications

Stefan Größ

6 joint publications

Louis M. Staudt

4 joint publications

Hua Yang

4 joint publications

Affiliations

Harvard University

US 1998 - 1998

Acorda Therapeutics (United States)

US 2021 - 2021

Agios Pharmaceuticals (United States)

US 2023 - 2009

Millennium Engineering and Integration (United States)

US 2010 - 2002

Ribon Therapeutics (United States)

US 2021 - 2021

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Lenny Dang

Publication & Citation Trends

Most Cited Works

Publications

The Pyruvate Kinase (PK) Activator AG-946 Improves PK Properties and Red Blood Cell (RBC) Characteristics upon Ex Vivo treatment of RBCs from Patients with Myelodysplastic Syndromes OA

Mitapivat reprograms the RBC metabolome and improves anemia in a mouse model of hereditary spherocytosis OA

Structure‐Based Design of AG‐946, a Pyruvate Kinase Activator

P1485: PKM AND PKR EXPRESSION DURING HEMATOPOIESIS AND ERYTHROPOIESIS OA

P717: AG946, A PYRUVATE KINASE (PK) ACTIVATOR IMPROVES PK PROPERTIES AND RED BLOOD CELL (RBC) METABOLISM UPON EX VIVO TREATMENT OF RBCS FROM PATIENTS WITH MYELODYSPLASTIC SYNDROMES OA

Mitapivat, a pyruvate kinase activator, improves transfusion burden and reduces iron overload in β-thalassemic mice OA

AG-946, an Activator of Pyruvate Kinase, Improves Ineffective Erythropoiesis in the Bone Marrow of Mouse Models of Myelodysplastic Syndromes OA

AG-946 Normalizes Glycolysis and Improves Red Cell Indices in a Humanized Sickle Cell Mouse Model OA

A Phase 1 Dose Escalation Study of the Pyruvate Kinase Activator Mitapivat (AG-348) in Sickle Cell Disease. OA

Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model. OA

Research Topics

Frequent Co-Authors

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